WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

ISSN 2457-0400

Impact Factor  :  6.711

News & Updation

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in WJAHR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR April 2024 Issue has been Published, Kindly check it on https://www.wjahr.com/home/current_issues

  • .

    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • WJAHR: New Impact Factor

    WJAHR Impact Factor has been Increased to 6.711 for Year 2024.

  • WJAHR: APRIL ISSUE PUBLISHED

    APRIL 2024 Issue has been successfully launched on 1 APRIL 2024.

Best Paper Awards

World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

Download Article : Click here

Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

ESTABLISHED LEAF FLAVONOIDS AS PHYTOLIGANDS FROM ANDROGRAPHIS PANICULATA (BURM. F.) WALL. EX NEESFOR ANTIBACTERIAL ACTIVITY AGAINST BACTERIAL DNA-GYRASE B RECEPTOR: AN IN SILICO APPROACH

Debojyoti Roychowdury*, Partha Talukdar and Soumendra Nath Talapatra

ABSTRACT

The medicinal plant,Andrographis paniculata(Burm. f.) Wall. Ex Neesis a common herbal plant having several medicinal properties in the leaves of plant.The medicinal properties are depending upon by the presence of several phytochemicals. Among different medicinal values,potent antibacterial properties are known as natural antibacterial agents. The objective of the present study was to detect receptor-ligand binding energy and interaction through molecular docking for lead phytocompounds established in the leaf of A. paniculata against bacterial DNA gyrase B protein (PDB ID: 3G7B). Molecular docking was performed by usingsoftware (iGEMDOC, Version 2.1) to detect binding energy and interaction.The interaction with residues was visualized in the AutoDoc tool (Version 1.5.6). Among 9 phytochemicals and 1 antibiotic (Ciprofloxacin), highest binding energy value was obtained in 5-hydroxy-7,8,2',5'-tetramethoxy-flavone (-121.862 Kcal/mol) when compared to Ciprofloxacin (-106.621Kcal/mol). The binding interaction of target protein with this phytocompound found binding at the active site due to competitive inhibition. In conclusion, phytocompound 5-hydroxy-7,8,2',5'-tetramethoxy-flavone can be alternative of synthetic antibacterial drug as per binding energy value and residue interaction. It is suggesting further pharmacological and toxicological assay with this phytocompound after isolation from medicinal plant (A. paniculata).

[Full Text Article] [Download Certificate]