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Abstract
A CASE REPORT OF MULTIFOCAL MOTOR NEUROPATHY WITH CONDUCTION BLOCKS (MMNCB) ON LONG TERM IMMUNOTHERAPY (WITH REVIEW OF LITERATURE)
Dr. Omar Farooq DM, *Dr. Mahpara MBBS and Dr. Aamir Malik MBBS
ABSTRACT
Multifocal motor neuropathy (MMN) with conduction block is an acquired immune-mediated demyelinating neuropathy with slowly progressive weakness, fasciculations, and cramping, without significant sensory involvement. Clinically, it may resemble ALS with predominant lower motor neuron involvement, but muscle atrophy and more rapid progression are lacking. Duration of disease prior to diagnosis ranges from several months to more than 15 years. Unlike ALS, MMN usually responds to treatment with intravenous immunoglobulin (IVIG) or cyclophosphamide, even after many years of duration. The patient discussed here is a 42- year old male who presented to our OPD as a case of slowly progressive weakness which started in his right foot 9 years back that was followed by weakness of his right hand without any sensory involvement. Patient was evaluated thoroughly and the diagnosis of MULTIFOCAL MOTOR NEUROPATHY WITH CONDUCTION BLOCKS (MMNCB) was made. Patient was treated with IVIG and showed dramatic improvement. Patient has been on IVIGs from last 5 years and is doing well.
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