WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Hiba R. Kamal* and Thikra A. Allwsh

ABSTRACT

Introduction: Dickkopf-3 (DKK-3) participates in cell signaling pathways, inflammation, and tissue remodeling, secreted within the renal tubular membrane in response to stress and a gradual reduction in kidney function typifies chronic kidney disease. The study aimed to evaluate the Dickkopf-3 level in serum of Mosul Patients' Chronic Renal and the effect of many factors on its. Methods: The study established specific criteria for the participation of 150 participants, encompassing individuals of both sexes aged 30 to 70 years. The participants were categorized into 2 groups: 75 healthy individuals and 75 patients with CKD. Tests were conducted to assess the levels of renal function, DKK-3 in the serum, and qPCR for the DKK-3 gene. Results indicated chronic kidney patients demonstrated a significant increase in Age, blood pressure (BP), and BMI, in addition to renal function: GFR, creatinine, urea Cystatin-C, uric acid, Albumin, and total protein compared to a control group. An inverse relationship exists between BMI and age with DKK–3 serum and an increase in DKK–3 in smokers in control and patient groups. There was a significant increase in levels of DKK-3 in patients' group serum compared to the control group at (p ≤ 0.001) depending on BMI, age, sex, and smoking. The study's results also showed an increase in the level of DKK3 in patients, which is considered one of the main reasons for the development of the pathological condition. Conclusion: The study suggests that DKK-3 correlates with decreased kidney function and clinical symptoms. The high DKK3 in the serum of patients may indicate the onset and progression of kidney disease. As a result, DKK-3 may be a potential target for treatment.

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