WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Arhoghro Ejovwoke Marcellinus*, Eric Emmauel Uchenna, Madock Obebinaru Joshua, Onitsha E. N., Berezi E. Peter

ABSTRACT

The study's goal was to investigate the effects of plantain stem juice on albumin protein and lipid profiles in rats with liver damage and oxidative stress caused by aluminum chloride. The study used fifteen female Wistar rats, which were separated into three groups: a control group that did not get any therapy, a group that had a dosage of 100 mg/kg/body weight of aluminum chloride (AlCl3) treatment, and another group that received both aluminum chloride and plantain stem juice at 2 mL/kg. Furthermore, every group was granted free access to food and hydration for a period of fourteen days. At the end of the experimentation period, we euthanized the experimental rats to collect liver and venous blood samples. The results showed significant changes in different parameters among the groups. It was found that in the A1C13 treated groups, triglyceride levels dropped from 77.78±1.49 mg/dl to 49.68±1.07 mg/dl, total cholesterol levels dropped from 67.83±1.39 mg/dl to 43.73±0.99 mg/dl, total protein levels dropped from 92.81±1.36 mg/dl to 51.02±0.95 mg/dl, albumin levels dropped from 8.25±1.05 mg/dl to 4.91±0.08 mg/dl, and SOD levels dropped from 5.75±1.32 Units/mg protein to 3.66±10.88 Units/mg protein. Conversely, there was a significant increase (P<0.05) in MDA levels, increasing from 401.08±0.99 to 1207.98±1.39 (nmol/mg protein). On the other hand, the experimental group that received M. paradisaca showed a significant increase in SOD, triglyceride, total protein, albumin, and total cholesterol concentrations. The use of M. paradisaca resulted in the restoration of measured parameters to their normal range, suggesting that this plant has potential as a therapy for chemical toxicity.

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