WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

INVIVO PHARMACOLOGICAL SCREENING OF HERBAL EXTRACTS AGAINST NEUROPATHIC PAIN

V. Swathi*, J. N. Suresh Kumar, S. K. Dilshad, S. K. Abdul Sattar and S. K. Karimulla

ABSTRACT

Neuropathic Pain (NP) is defined as "Pain that is brought on by a primary nervous system lesion or dysfunction."It is majorly observed as co-morbidity with diabetes, rheumatoid arthritis and others. A few drugs are used intreatment with side effects. Recent investigations are focusing light on NP. Solanum melongena and Solanumlycopersicum are popular medicinal herbs employed for treating various diseases. The present research focuses onscreening of leaves of Solanum melongena and Solanum lycopersicum for neuropathic pain. The extraction isperformed using continuous hot percolation with ethanol as menstrum. The extracts are subjected forphytochemical screening in order to evaluate the type of phytoconstituent present in it. Screening for neuropathicpain property is performed using Formalin induced paw flinching behaviour and AITC induced paw oedemamodels. Formalin and AITC acts as inducers for neuropathic pain by stimulating TRP channels in nerves. Theinflammatory volume observed in group of animals treated with Solanum melongena leaf extract at dose of400mg/kg showed maximum activity in both the models indicating a decline in oedema and flinching behaviourcompared with other extracts. A mild increase in response is observed when compared with standard values. TheSolanum melongena leaf extract at dose of 400mg/kg showed good Neuropathic Pain property.

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