WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

V. Swathi*, J. N. Suresh Kumar, S. K. Dilshad, S. K. Abdul Sattar and S. K. Karimulla

ABSTRACT

Neuropathic Pain (NP) is defined as "Pain that is brought on by a primary nervous system lesion or dysfunction."It is majorly observed as co-morbidity with diabetes, rheumatoid arthritis and others. A few drugs are used intreatment with side effects. Recent investigations are focusing light on NP. Solanum melongena and Solanumlycopersicum are popular medicinal herbs employed for treating various diseases. The present research focuses onscreening of leaves of Solanum melongena and Solanum lycopersicum for neuropathic pain. The extraction isperformed using continuous hot percolation with ethanol as menstrum. The extracts are subjected forphytochemical screening in order to evaluate the type of phytoconstituent present in it. Screening for neuropathicpain property is performed using Formalin induced paw flinching behaviour and AITC induced paw oedemamodels. Formalin and AITC acts as inducers for neuropathic pain by stimulating TRP channels in nerves. Theinflammatory volume observed in group of animals treated with Solanum melongena leaf extract at dose of400mg/kg showed maximum activity in both the models indicating a decline in oedema and flinching behaviourcompared with other extracts. A mild increase in response is observed when compared with standard values. TheSolanum melongena leaf extract at dose of 400mg/kg showed good Neuropathic Pain property.