WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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Indexing

Abstract

FORMULATION AND EVALUATION OF FLOATING MICROBALLOONS FOR ANTI GOUT DRUG

Maitry Sheth, Femin Sailor, Hitesh Jain*, Sharav Desai and D. B. Meshram

ABSTRACT

Microballoons are considered as one of the most promising buoyant drug delivery systems as they possess the advantages of both multiple-unit systems and good floating properties. The purpose of the present investigation was to characterize and evaluate microballoons of Allopurinol and to increase its boioavailability by increasing the retention time of the drug in the gastrointestinal tract. Sustained release floating microballoons containing allopurinol was formulated by solvent evaporation method using different polymer, DCM and ethanol as organic solvents and tween 80 as a processing medium. The prepared batches were evaluated for particle size, % entrapment efficiency, drug loading, floating time, total floating time and in-vitro drug release. The % entrapement efficiency was found to be 63.6 % to 84.83 %. Drug loading was found the range of 55.81 to 88.56 %. All the prepared microballoons remain on float condition over a period of 12 hrs. Formulation F1 showed the highest drug release of 83.93 % in 12 hrs. All other physical parameters were found satisfactorily. The results showed that the prepared floating microballoons of Allopurinol prove to be potential multiple-unit delivery devices for safe and effective sustained drug delivery.

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