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THE RELATIONSHIP BETWEEN TYPE 2 DIABETES MELLITUS AND GALLSTONES: A CROSS-SECTIONAL STUDY
*Sobhi Alliwa, Arige Boubou and Hassan Zayzafon
Background: Diabetes and gallstones are among the most common and costly diseases. Several studies found an increased prevalence of gallstones in diabetics, but with a high variation in percentages. The results of these studies were also inconsistent concerning potential risk factors for gallstone formation in type 2 diabetes mellitus (T2DM) patients, such as age, gender, and obesity. Aim of the study: This study aimed to assess the prevalence of Gallstones in T2DM patients and the associated risk factors such as age, gender, duration of diabetes, HbA1c level, parity, family history of gallstones, obesity, and dyslipidemia. Materials & Methods: A cross-sectional study included 243 T2DM patients who attended Tishreen University Hospital from 1st February 2020 to 1st September 2021. We performed a comprehensive clinical examination, measurement of height and weight. Venous blood samples were drawn after a 12-hour fast: ALT, AST, triglycerides, total cholesterol, HDL, HbA1c, TSH, blood sugar, CBC, Creatinine. An abdominal ultrasound was also performed after A 8 hours fast to look for gallstones or Biliary sludge. Results: The prevalence of gallstones in T2DM patients was 25.5%. Advanced age, increased duration of diabetes, obesity, multiple parity, family history of gallstones, high total cholesterol and triglyceride levels, as well as low levels of HDL were associated with a high risk of gallstones in patients with type 2 diabetes. The gallstones prevalence was 29% in women and 20.4% in men, but this difference was not statistically significant. A high level of HbA1c was not a risk factor for gallstone formation. Conclusion: Patients with type 2 diabetes have a higher prevalence of Gallstones than non-diabetics.[Full Text Article]