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Abstract
PROGNOSTIC SIGNIFICANCE OF BCL-2 AND BCL-6 IMMUNOSTAINING IN B-CELL NON-HODGKIN’S LYMPHOMA
Reem Kafa, MD*, Firas Hussein, MD and Ali Daoud, MD
ABSTRACT
Purpose: The aim of this study was to identify a possible effect of Bcl-2 and Bcl-6 proteins on the clinical behavior and outcome in different subtypes of B-cell non-Hodgkin lymphoma (B-NHL). Methods: We retrospectively studied Bcl-2 and Bcl-6 expression by immunohistochemistry (IHC) in 145 patients with diffuse large B-cell lymphoma (DLBCL), 86 patients with follicular lymphoma (FL), and 53 patients with mantle cell lymphoma (MCL), and analyzed their prognostic relevance and effect on treatment response in these cohorts. Results: Positive Bcl-2 expression related strongly to lower rates of complete response (CR) after first-line treatment with Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in both DLBCL (p=0.001) and MCL (p=0.01). Bcl-2 was recognized as an independent predictor of poor overall survival (OS) (HR=2.9, p
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