WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Walaa Mayhob*, Ibrahim Sulaiman and Suzanne Alshemali

ABSTRACT

Objective: The aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and progression to dialysis in patients with chronic kidney disease(CKD)stage1-4. Patients and Methods: Prospective Analytical Study conducted for the period one year(April 2020 – April 2021) at Tishreen University Hospital in Lattakia-Syria. The study included 128 patients with CKD stage 1-4. Results: The median age was 64 years, males represented 56.3 % of the patients, and 61.7% were graded in the stage IV with median duration of disease 24 month. Hypertension was the most frequent co-morbidities(82.8%). When the peak NLR reached 4.8, progressive of disease could be predicted with an area under the ROC curve of 0.69(95% CI:0.57-0.76) with sensitivity 67.2% and specificity 62.9%. NLR >4.8 was associated significantly with increased risk of decreasing glomerular filtration rate(GFR). NLR was associated with the risk of occurrence ESRD in patients with stage 4 CKD: HR 2.3(95% CI 0.2-3.9),P:0.01. Conclusion: Our study findings demonstrated that progression of kidney disease is significantly associated with inflammation, and NLR could be candidates for predicting renal outcomes in patients with CKD stage 1-4.