WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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    Venue: FCT Education Resource Center, Abuja-Nigeria

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Indexing

Abstract

THE RELATIONSHIP BETWEEN NEUTROPHIL TO LYMPHOCYTE RATIO AND DISEASE PROGRESSION IN PATIENTS WITH STAGE 1-4 CHRONIC KIDNEY DISEASE

Walaa Mayhob*, Ibrahim Sulaiman and Suzanne Alshemali

ABSTRACT

Objective: The aim of this study is to investigate the association between neutrophil to lymphocyte ratio (NLR) and progression to dialysis in patients with chronic kidney disease(CKD)stage1-4. Patients and Methods: Prospective Analytical Study conducted for the period one year(April 2020 – April 2021) at Tishreen University Hospital in Lattakia-Syria. The study included 128 patients with CKD stage 1-4. Results: The median age was 64 years, males represented 56.3 % of the patients, and 61.7% were graded in the stage IV with median duration of disease 24 month. Hypertension was the most frequent co-morbidities(82.8%). When the peak NLR reached 4.8, progressive of disease could be predicted with an area under the ROC curve of 0.69(95% CI:0.57-0.76) with sensitivity 67.2% and specificity 62.9%. NLR >4.8 was associated significantly with increased risk of decreasing glomerular filtration rate(GFR). NLR was associated with the risk of occurrence ESRD in patients with stage 4 CKD: HR 2.3(95% CI 0.2-3.9),P:0.01. Conclusion: Our study findings demonstrated that progression of kidney disease is significantly associated with inflammation, and NLR could be candidates for predicting renal outcomes in patients with CKD stage 1-4.

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