WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

Abstract

FORMULATION AND EVALUATION OF TERBINAFINE HYDROCHLORIDE EMULGEL FOR TOPICAL DRUG DELIVERY

Pinky Bisht*, G. Gnanarajan

ABSTRACT

Terbinafine is a broad spectrum antifungal drug. Terbinafine hydrochloride is an orally and topically active drug belonging to allylamine class of antifungal effective against dermatophytes and candida group of fungi. The aim of research work is the formulation and evaluation of Terbinafine Hydrochloride emulgel for topical drug delivery using different concentration of excipients to avoid hepatic first pass metabolism, improve stability of emulsion, reduce dosage regimen and enhance residence time in the treatment of fungal infecton. The compatibility of drug with excipients was studied by FTIR spectroscopy. Formulations were prepared composed of carbopol 934 as gelling agent, liquid paraffin used as vehicle (oils), surfactants (span 20,tween 20) ,emulsifier or co- surfactant(propylene glycol), preservatives(methyl paraben, propyl paraben),solvent(ethanol),triethanolamine. All the different formulations were prepared by varying concentration of (polymer,emulsifier,surfactants and co surfactants).Polymer can function as emulsifiers and thickeners because the gelling capacity of these compounds allows the formulations of stable emulsions and creams by decreasing surface and interfacial tension and at the same time increasing the viscosity of the aqueous phase. In fact the presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. The effect of concentration of the oil phase and emulsifying agent on the drug release was investigated using a 22 factorial design. The Terbinafine HCl emulgel formulation with the oil phase concentration 8%w/v and emulsifying agent concentration 3.5% w/w was the formula suggested as an optimized formulation by design expert software. All the prepared emulgels showed satisfactory physicochemical properties like colour, homogeneity,consistency, spreadability and pH value. The pH of prepared emulgel was found in the range of 5.4±0.66 to 6.3±0.9, drug content of all the prepared emulgel was found in the range of 87.34±1.5% to 94.72 ± 0.3%. In-vitro release results revealed that 91.51% to 97.31% of drug released from the formulations in 6 hrs.study. By observing the values of n it was confirmed that the Non Fickian diffusion is dominant in all formulations from F1 to F4.

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