WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

Abstract

FORMULATION AND IN VITRO EVALUATION OF SUSTAINED RELEASE MICROPARTICLES OF LOXOPROFEN SODIUM

Sherbaz Bilal, Pharm-D, Qaiser Iqbal, PhD* and Syed Umer Jan, PhD

ABSTRACT

Background: Loxoprofen sodium is an essential NSAID which is 2-arylpropionoc acid derivative. It owns a very short half-life and principally used for treating osteoarthritis & rheumatoid arthritis. So far there is no loxoprofen sodium‘s modified release dosage form available and is commercialized as tablets and transdermal patches only. Objective: The aim of this study was to develop and characterize the sustained and prolonged release microparticles of loxoprofen sodium by utilizing HPMC as a bio-polymer. Methods: Coacervation-phase separation technique was used in this study. The prepared microparticles went through in-vitro evaluation to observe the outcome of various parameters (polymer to drug ratio, stirring speed, and stirring time) on the physiochemical behaviors of prepared micro particles. Prepared microparticles exhibited excellent encapsulation efficiency and percentage yield, i.e. up to 91.71% & 88.94% respectively. Micrometrics examination showed the evidence of good flow characteristics of microparticles. By using USP defined dissolution apparatus at pH 6.8 for 12 hours at 37 ± 0.5°C dissolution studies for the prepared formulations were performed. The accumulative drug release was retarded with the increase in drug to polymer ratio during observation. Most of the prepared batches were in pursuit of higuchi model of release trough Fickian diffusion model. The optimal batch F6 was selected for further assessment FTIR, SEM and XRD. Results and Discussion: FTIR results showed no interaction between polymer and drug. XRD proved the stability of the product. Scanning electron micrographs depict that the particles had, heterogeneous, irregular and porous surface. Mean diameter was calculated as 200 ?m. Thus the microparticles were prepared successfully using best polymer and technique.

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