WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
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ISSN 2457-0400

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Indexing

Abstract

PREPARATION & EVALUATION OF ERYTHROMYCIN MICROEMULSION FOR OCULAR DRUG DELIVERY

*Pawan Bhandari, Dr. Ashutosh Badola

ABSTRACT

The aim of the present study is to prepare and evaluate erythromycin microemulsion for ophthalmic drug delivery. Microemulsions are in focus of recent research due to its advantages like it reduces the risk of toxicity, reduced dosing frequency, and the tendency to load both hydrophilic and lipophilic drugs.The first step in the current research was the preformulation studies of the drug. The given drug was subjected for different preformulation tests like organoleptic properties, melting point, determination of absorbance maxima (?max) by UV, preparation of standard curve in different solvents, FTIR, partition coefficient and solubility. After confirmation of the given drug, erythromycin loaded microemulsion was successfully prepared. Delivery of drugs into eyes using conventional dosage form or conventional drugs eg.solutions is a complicated and considerable challenges to the scientist for the treatment of ocular diseases. In Ocular drug delivery system the scientist faced many challenges due to unique structure, anatomy and physiology of eye. The aim of the present study was to develop Erythromycin Microemulsion for Ocular drug delivery. Micro emulsions (ME) are thermodynamically stable and clear mixtures of oil, surfactants, and water sometimes also available in combination with co surfactants. Erythromycin belongs to the class of Macrolide antibiotics & drug delivery through microemulsion via ocular enhaned bioavailability. The main objective of the present investigation was to formulate and characterise microemulsion for ocular drug delivery. 70% of the ophthalmic preparations are conventional dosage forms, extensive pre corneal loss caused by rapid drainage and high tear liquid are the main drawbacks associated with these systems, only 1 to 5% of the total drug penetrates into cornea and reaches to the intraocular tissue, to overcome these problems, microemulsion based systems are developed. The microemulsion was prepared by using different ingredients are as follows: oleic acid as an oil phase, tween 80 as surfactant, ethanol as co surfactant and 0.5 N NAOH as aqueous phase. The optimization and formulation chart was carried out using 23 factorial design. The microemulsions was prepared by using different ratios of oil and surfactant/co surfactant with water. The prepared microemulsions was evaluated for particle size, viscosity, and pH and % drug content. The particle size of prepared microemulsions was found in micro range that is from 12.11 to 650.6 d.nm. Drug content of all the prepared microemulsions was ranged from 79.55% to 95.56%. In formulation FI and F5, by observing the value of n it was confirmed that the anomalous transport is dominant. Therefore it was concluded that prepared formulations was able to provide better management of eye diseases and hence improve patient compliance. After performing all evaluation parameters and observing every experimental results, formulation F1 was selected as optimized formulation. Therefore it was concluded that the optimized erythromycin microemulsion was effective in the treatment of eye diseases.

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