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PHYTOSOMES: EFFECTIVE SYSTEM FOR THE TARGETED DELIVERY OF BIOACTIVE PLANT EXTRACTS
Madhukar Shende*, Chandrashekhar Shende, Aparna Shende, Satish Bodele, Nilesh Ashokrao Nalawade
Due to low lipid solubility and molecular size, herbal medicines with a high concentration of active components exhibit significant bioactivity in vitro but limited bioactivity in vivo. As a consequence, the herbal extract's active ingredients are poorly absorbed and accessible. Phytosomes are a phytophospholipid complex vesicle that may increase the bioavailability of herbal extracts and phytoconstituents in medicines. Phytosomes are advanced herbal formulations that contain the bioactive phytoconstituents of herbal extracts and have the ability to shift the cell membrane from a hydrophilic to a lipophilic state, resulting in a more potent pharmacokinetic and pharmacodynamic profile than traditional herbal extracts. They are available in a variety of forms, including suspensions, pills, creams, and gels. The goal of this article is to provide a thorough research on phytosomes as a potential drug delivery mechanism by discussing current developments in phytosomes as well as their usage in various standardized herbal extracts.[Full Text Article]