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An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

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    Its our Pleasure to Inform you that WJAHR Impact Factor has been increased from  4.897 to 5.464 due to high quality Publication at International Level

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    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

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    SEPTEMBER 2021 Issue has been successfully launched on 1 September 2021.

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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

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Dr. Chintan Himmatbhai Desai*


Hypophosphatasia is a rare, inherited metabolic disorder in which patients have deficient tissue nonspecific alkaline phosphatase (TNAP) enzymatic activity. Oral manifestations characteristic of various forms of hypophosphatasia can include early loss of deciduous teeth, severe dental caries, and alveolar bone loss. ? In its severest forms (occurring in 1 in 100,000 live births), hypophosphatasia is associated with impaired bone/tooth mineralization and rickets-like symptoms, seizures, and failure to thrive; based on historical data, patients with severe, early onset (i.e., younger than 6 months) forms of the disorder have a high 5-year mortality rate (73%), generally from respiratory failure. ? In 2015, the U.S. Food and Drug Administration (FDA) approved a recombinant form of TNAP enzyme replacement therapy called asfotase alfa (Strensiq®, Alexion Pharmaceuticals, Inc.) for subcutaneous administration in patients with perinatal, infantile, and juvenile-onset forms of hypophosphatasia. ? Treated patients show improvements in overall survival and survival free from invasive mechanical ventilation compared with historical controls. ? Adverse events include injection-site and hypersensitivity reactions and ectopic calcifications in the eye and kidneys. ? X-linked hypophosphatemia, also known as vitamin D-resistant rickets, is an inherited disorder characterized by low levels of phosphate in the blood due to abnormal processing in the kidney, leading to phosphate wasting and resulting in soft, weak bones (rickets). ? X-linked hypophosphatemia is usually diagnosed in childhood and its features can include bowed or bent legs, short stature, bone pain, and severe dental pain, as well as other oral manifestations that include spontaneous dental abscesses. ? In 2018, the FDA approved burosumab-twza (Crysvita™, Ultragenyx Pharmaceuticals, Inc.), a monoclonal antibody that inhibits activity of excess fibroblast growth factor 23, thereby restoring normal renal phosphate processing for adult and pediatric individuals with X-linked hypophosphatemia. ? Treated patients show improvements in serum phosphate levels and radiologic findings, compared to placebo treatment or to historical controls. ? Adverse events include injection-site reaction, headache, and decreased circulating levels of vitamin D.

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