WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
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Indexing

Abstract

INSIGHT INTO THE ROLE OF SERUM MAGNESIUM IN GLYCEMIC CONTROL OF TYPE 2 DIABETES MELLITUS

Dr. Reena R.*, Dr. Usha S.M.R., Dr. Manjula K.S., Dr. H.V.Shetty

ABSTRACT

Background: Intracellular magnesium (Mg2+), a macro mineral plays a key role in regulating insulin action. Thus magnesium deficiency can contribute to insulin resistance. In this regard we have studied the serum magnesium levels to know its relationship with type 2 diabetes mellitus (type 2 DM) and also to evaluate its association with the glycemic control. Materials and Methods: One hundred and fifty subjects in the age group of 35-60 years attending medical OPD of Rajarajeswari Medical College and Hospital, Bengaluru, were included in the study. Hundred, type 2 DM patients were divided into two groups; group I -consisting of fifty subjects with poor glycemic control and group II- fifty subjects with good glycemic control. Fifty, non-diabetic apparently healthy volunteers were considered as group III. Serum FBS and PPBS was estimated by GOD-POD method, Glycosylated Hemoglobin (HbA1c) by particle enhanced immunoturbidimetric method and Serum Magnesium by Xylidil blue spectrophotometric method. Results: Mean serum magnesium level was 1.97 ± 0.43 mg/dl and 2.0 ± 0.22 mg/dl in type 2 DM patients and non-diabetic healthy volunteers respectively. Though there was no significant difference in serum magnesium levels between the three study groups, incidence of hypomagnesemia was high (38%) in diabetic group compared to non-diabetic healthy volunteers (12%). Group I subjects had high incidence of hypomagnesemia (40%) than group II (36%). Conclusion: Hypomagnesemia is common among type 2 diabetics irrespective of glycemic control. This incidence is multifactorial and needs further investigation in larger population.

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