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PREVALENCE OF ANEMIA IN PRIMARY HYPOTHYROIDISM PATIENTS
Seraj Faek Jded*, Munif Al-Meri and Tagrid Kaddar
Background: Even though the association between primary hypothyroidism and anemia is commonly described, it is not known whether it is clinically relevant especially in subclinical hypothyroidism. Objectives: In this study, we evaluate the prevalence of anemia and if present, etiology of anemia in patients with primary hypothyroidism. Methods and patients: 174 patients with clinical and laboratory sighs of hypothyroidism presented to Endocrinology and Metabolic Diseases outpatient clinic of Tishreen University Hospital in Lattakia-Syria from January 2020 to January 2021. 85 patients with overt Hypothyroidism, 89 patients with subclinical Hypothyroidism were enrolled in this Study. All patients were subjected to full medical history, clinical examination, biochemical studies. Hypothyroidism was defined as TSH ?4.5 mIU/L (subclinical [SHypo] with normal fT4 or overt [OHypo] with low fT4), Anemia was defined as Hb <12 g/dL in non-pregnant women and Hb <13 g/dL in men. Results: Anemia prevalence was 47.05% in the overt hypothyroid group, 13.48% in the subclinical hypothyroid group p-value=0.0001. Anemia of chronic disease was present in 30 patients (57.7%) followed by iron deficiency anemia in 20 patients (38.5%)and two patients (3.8%) had megaloblastic anemia with vitamin B12 deficiency. There was no difference between the hypothyroid groups in terms of anemia. Conclusions: The frequency of anemia in over hypothyroidism patients was high but Subclinical thyroid dysfunction was not an independent risk factor for developing anemia. Anemia of chronic disease is the most common type of anemia in hypothyroid patients, followed by iron deficiency anemia.[Full Text Article]