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STUDY OF SERUM MAGNESIUM LEVELS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Firas Ibrahim Kiwan*, Malek Hejazie, Muhammed Imad Khayat
Objective: The aim of this study is to assess the serum magnesium levels in chronic obstructive pulmonary disease (COPD) patients during stable and exacerbating clinical conditions. Patients and Methods: Case- Control Study conducted for the period one year(April 2019-April2020) at Tishreen University Hospital in Lattakia-Syria. 160 patients(109 male, 51 female) diagnosed as COPD, divided into group I(50): stable COPD and group II (110):exacerbated COPD. Group III consists of 60 healthy smoker persons(51 male, 9 female) as a control group. Results: Mean serum magnesium level for exacerbated COPD(1.73±0.1 mEq/L) was significantly lower than in stable COPD patients group(2.02±0.1 mEq/L) and control group(2.23±0.1 mEq/L). Pearson's correlation analysis revealed significant positive correlation between serum magnesium level and FEV1 (r =0.69, P=0.0001) and FEV1/FVC(r: 0.52, p:0.0001). In addition to, magnesium level showed negative correlation with number of exacerbations in year(r: -0.79, P=0.0001) and cigarette pack per year(r:-0.67, p:0.0001). Conclusion: Serum magnesium levels might be as a useful biomarker in assessing severity of COPD, in which frequency of acute exacerbations correlate with severity of hypomagnesemia.[Full Text Article]