WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Shalini Sondhiya*, Dr. Arun Patel, Shailendra Patel, Dr. Neelesh Dwivedi

ABSTRACT

The objective of this review is to provide the overview of the role of natural polymers in gastroretentive drug delivery system (GRDDS), its characteristics, ongoing research, trend of future developments, and applications in the field. Appropriate articles were searched from Medline database using the search term "Natural Polymer and Gastric,” The approach of various natural polymers in industrial applications such as medicine and similar areas is growing rapidly in this era. It was observed biodegradable and non-toxic materials like t he natural polymers are evident by the mounting level of its use in the pharmaceutical field. Using various natural polymers has been aiding the drug delivery systems for prolongation of time as the drug transporters with the objective of improving bioavailability and therapeutic efficacy. The use of natural polymers in novel drug delivery like GRDDS to possess floating or mucoadhesive in the gastric system for the benefit of increasing gastric resident time and to improve therapeutic efficacy, particularly those drugs are having narrow therapeutic index such as carvedilol, itopride, and glipizide. The physical characteristics of natural polymers facilitates sustained, swelling, and mucoadhesive nature based on literature reviewed, therefore, natural polymers also suitable to GRDDS as like synthetic or semi-synthetic polymers. This review having lots of natural polymers like Guar gum, Tragacanth, Karaya gum, Pectin, Na Alginate, Gelatin, Xanthan gum, Gellan gum, Grewia gum, Carrageenan, Locust bean gum etc.

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