WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Academia , Scope Database , 

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

OFF LABEL USE OF DIRECT ORAL ANTICOAGULANTS (DOACS) COMPARED TO VITAMIN K ANTAGONIST (VKA) FOR LEFT VENTRICULAR THROMBUS (LVT): A SYSTEMATIC REVIEW AND META-ANALYSIS

Abdulkareem AlGarni, Abdulmajeed Aljuhiman and Dr. Ayman F. Soliman*

ABSTRACT

Background: Left ventricular (LV) thrombus is associated with high burden of stroke, systemic embolization and mortality. Direct oral anticoagulants (DOACs) has emerged as an alternative treatment to Vitamin K Antagonist (VKA). In absence of randomized controlled trials, we aim to conduct systematic review and meta- analysis for the available observational studies. Objective: to evaluate effectiveness and safety of DOACs Versus VKA in Setting of LV thrombus. Methods: We searched Ovid Medline, Embase, PubMed, Google scholar and ClinicalTrials.gov for comparative Observational studies of DOACs Versus VKA in LV thrombus treatment. Results: We found 9 eligible observational studies including 2160 patients reported as 4 published studies and 5 abstracts without full report. Meta-analysis showed no difference between two interventions in terms of stroke and systemic embolization (SSE) RR= 1.09, 95% CI (0.90 –1.31), thrombus resolution RR= 1.01, 95% CI (0.62-1.63) and Major bleeding events RR =1.06, 95% CI (0.66-1.71). Conclusion: There is no difference between DOACs and VKA in terms of effectiveness and safety for treatment of LV thrombus. Randomized controlled trial is needed to evaluate DOACs in the treatment of LV thrombus.

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