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Abstract
NATURAL POLYSACCHARIDES (A VITAL PHARMACEUTICAL EXCIPIENT FOR COLONIC DRUG DELIVERY)
Gharge Varsha* and Savitri Pol
ABSTRACT
Colon specific drug delivery system offers several advantages in the treatment of colonic diseases such as ulcerative colitis, amoebiasis, Crohn’s disease, irritable bowel syndrome, colorectal cancer. The polysaccharides based colon specific drug delivery is relatively easy due to the presence of various derivatizable groups, wide range of molecular weights, varying chemical compositions, low toxicity and high stability. Natural excipients present various advantages over the synthetic as they are inert, safe, non-toxic, biocompatible, biodegradable, low cost, ecofriendly and abundantly available in nature. In the present review different natural excipients were studied in terms of their use in various formulations for different purposes.
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