WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

Abstract

LEFT VENTRICULAR DYSFUNCTION IN HYPOTHYROID PATIENTS

Ali Alzarka*, Akram Jahjah and Rouba Salman

ABSTRACT

Background: The heart is a very sensitive organ to thyroid hormones, any change in thyroid function can cause adverse cardiovascular effects. Aim & Objective: studying the effects of overt and subclinical hypothyroidism on left ventricle (LV) systolic & diastolic functions. Material & Methods: A total of 43 cases of recently diagnosed hypothyroidism patients (28 overt and 15 subclinical) with 43 age sex matched healthy control subjects were included in this study. Serum TSH, FT3, and FT4 hormones levels were measured and both those with hypothyroidism and healthy subjects underwent for 2D Echocardiography and the same was done for the controls. Results: Systolic function of LV in hypothyroid patients was mostly normal without any statistical significance when compared to with control group. Diastolic dysfunction was noticed in patients groups with both types of hypothyroidism. In overt hypothyroidism, there was a statistically significant increase in IVRT [98.92±12.5 ms] VS. [78.32±9.9 ms] in control group (P<0.05), and a statistically significant increase in E/e’ ratio [9.55±3.6] VS. [5.87±1.2] in control group (P<0.05). In subclinical hypothyroid patients, there was a statistically significant increase in IVRT [92.33±11.3] VS. [78.33±10.9] in control group (P<0.05). We noticed a statistically significant increase in Myocardia performance Index(MPI) in both overt hypothyroid patients [0.47±0.04] VS. [0.39±0.04] in control group (P<0.05), and subclinical hypothyroid patients [0.45±0.03] VS. [0.38±0.03] in controls (P<0.05). Conclusion: In patients with hypothyroidism, in addition to compromised LV diastolic function, MPI was also increased which reflect both systolic and diastolic LV dysfunction.

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