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Best Article of current issue
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LEFT VENTRICULAR DYSFUNCTION IN HYPOTHYROID PATIENTS
Ali Alzarka*, Akram Jahjah and Rouba Salman
Background: The heart is a very sensitive organ to thyroid hormones, any change in thyroid function can cause adverse cardiovascular effects. Aim & Objective: studying the effects of overt and subclinical hypothyroidism on left ventricle (LV) systolic & diastolic functions. Material & Methods: A total of 43 cases of recently diagnosed hypothyroidism patients (28 overt and 15 subclinical) with 43 age sex matched healthy control subjects were included in this study. Serum TSH, FT3, and FT4 hormones levels were measured and both those with hypothyroidism and healthy subjects underwent for 2D Echocardiography and the same was done for the controls. Results: Systolic function of LV in hypothyroid patients was mostly normal without any statistical significance when compared to with control group. Diastolic dysfunction was noticed in patients groups with both types of hypothyroidism. In overt hypothyroidism, there was a statistically significant increase in IVRT [98.92±12.5 ms] VS. [78.32±9.9 ms] in control group (P<0.05), and a statistically significant increase in E/e’ ratio [9.55±3.6] VS. [5.87±1.2] in control group (P<0.05). In subclinical hypothyroid patients, there was a statistically significant increase in IVRT [92.33±11.3] VS. [78.33±10.9] in control group (P<0.05). We noticed a statistically significant increase in Myocardia performance Index(MPI) in both overt hypothyroid patients [0.47±0.04] VS. [0.39±0.04] in control group (P<0.05), and subclinical hypothyroid patients [0.45±0.03] VS. [0.38±0.03] in controls (P<0.05). Conclusion: In patients with hypothyroidism, in addition to compromised LV diastolic function, MPI was also increased which reflect both systolic and diastolic LV dysfunction.[Full Text Article]