WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
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Indexing

Abstract

THE RELATIONSHIP BETWEEN NEUTROPHIL TO LYMPHOCYTE RATIO AND GLYCEMIC CONTROL DEGREE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Ahmad Abed Alnabi*, Ruba Salman and Firas Hussain

ABSTRACT

Background: Type 2 diabetes mellitus(T2DM) is considered nowadays as one of the most important chronic disease, low grade inflammation is a common feature in subjects with T2DM. Neutrophil to lymphocyte ratio(NLR) may be indicative of an underlying inflammatory state which may attribute to the progression of insulin resistance. Objective: The present study aims to assess the association between NLR and the degree of glycemic control(HbA1C) in T2DM patients. Materials and Methods: This is Cross- sectional study conducted in the Department of Endocrinology in Tishreen University Hospital-Lattakia -Syria from October 2019 to October 2020. The study included 120 patients with T2DM and 120 matched age and sex controls. Results: The patients (45 males and 75 females) had a mean age 0f 55.04±8.04 years, disease duration 5.7±3.8 years. The NLR was significantly increased in T2DM patients(2.98±0.6) compared to the control(1.50±0.2) (p:0.0001). NLR was found to be higher in patients with HbA1C >9%( 3.68±0.2) compared to patients with HbA1C<7%(2.29±0.2) (p:0.0001), and in patients with duration of disease >10 year(3.29±0.4) compared to patients with duration <5 year(2.86±0.6) (p:0.01) . Using Pearson's correlation coefficient, NLR was found to increase significantly with increase in HbA1C(r:0.97 ,p:0.0001), and duration of disease(r:0.4,p:0.001) without significant correlation with body mass index(BMI )and age group. Conclusion: Our results suggest that NLR is associated with HbA1C and duration of disease. It is an easily accessible and useful marker for monitoring diabetes mellitus patients in clinical practice.

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