WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Tariq Mohammd Waffek

ABSTRACT

Objectives: Studies investigating the effects of intravenous (IV) ketamine with dexamethasone (IV) in pain management after septorhinoplasty. This studyaims to evaluate the efficacy of IV ketamine with IV dexamethasone on pain scores. Methods: This randomized, prospective, double-blind study was conducted with 90patients who underwent septorhinoplasty. IV dexamethasone 2 ml (2 ml/ 8 mg) with Intravenous ketamine bolus (0.5 mg/kg) was administered to the ketamine group (group K, n = 45), Perioperative. In the control group (group C, n = 45), the same protocol was administered using saline instead of ketamine and dexamethasone. Pain scores were evaluated with the visual analogue scale. Consumptions intraoperative of opioid and sevoflurane, rescue opioidrequirement, patient satisfaction, and side effects were recorded. Results: Pain scores were significantly lower in group K at all postoperative periods (P < 0.05). There was no significant difference between the groups in terms of intraoperative sevoflurane and remifentanil consumptions (P >.05). Rescue opioid analgesic requirements were significantly lower in group Kthan group C (0/45 vs 6/45, respectively; (P = 0.022). Side effects were similar between the groups (P > 0.05). Conclusion: We recommend the administration of ketamine with dexamethasone during septorhinoplasty surgery because it reduces the requirement for rescue opioid analgesia and postoperative pain scores.

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