WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

Abstract

CYTOKINES AND INFLAMMATORY MEDIATORS FOR MONITORING THE STATUS OF PERIODONTITIS

T. Y. Loo*, Xu Chunjiao and Mary N. B. Cheung

ABSTRACT

Objective: C-reactive protein is a sensitive and dynamic systemic marker of inflammation. Pro- and antiinflammatory cytokines have been well documented with initiation, control and susceptibility to periodontal diseases. This study applied high-sensitivity CRP (Hs-CRP), pro- and anti-inflammatory cytokines to predict risk of periodontal diseases. Methods: 2400 subjects (1200 healthy subjects and 1000 chronic periodontal patients) were recruited from Hong Kong, Xiangya School of Satomatology, Central South University, Changsha, China, respectively. Blood was drawn from subjects and DNA was extracted. The polymorphic sites of CRP, pro-inflammatory (interleukin-1? (IL-1?), IL-1?, tumor necrosis factor-? (TNF-?), IL-6 and IFN-?) and anti-inflammatory cytokines (IL-4, IL-10) were amplified and measured via polymerase chain reaction for further analysis. Chi-square test and logistic regression analysis were applied to analyze genotype distribution differences, allele frequencies and carriages rates between healthy and disease groups. Soluble protein levels of cytokines were evaluated by the t-test. Results: Genotype frequencies of CRP, pro- and anti-inflammatory cytokines was statistically higher in periodontal-diseased patients than healthy controls (p<0.05). Prevalence of periodontal diseases was statistically correlated with carriage of single nucleotide polymorphisms of the cytokine parameters. Conclusions: Hs-CRP and cytokine gene polymorphisms may be applied as biomarkers to predict periodontitis susceptibility, clinical behavior and severity.

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