WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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    Venue: FCT Education Resource Center, Abuja-Nigeria

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Indexing

Abstract

EFFICACY OF MONTELUKAST ADDED TO INHALED BUDESONIDE IN COMPARISON OF INHALED BUDESONIDEON CONTROL OF MILD TO MODERATE ASTHMA IN CHILDREN

*Narmin Hajo, Ghazal Dib and Amal Al-Hakim

ABSTRACT

Background: While Guideline recommends daily treatment of corticosteroids to control asthma symptoms, Montelukast, a leukotriene receptor antagonist, is effective in treating asthma symptoms. Objective: To test the hypothesis that combined administration of multiple doses of inhaled Budesonide and oral montelukast provides additional benefit compared with Budesonide alone in children patients with mild and moderate severity of persistent asthma. Methods: An open Randomized trails study included 120 patients presenting to the clinic at Tishreen University Hospital over one year from March 2020 to March 2021. The patients were randomized to two equal groups: inhaled Budesonide only (group A) and inhaled Budesonide with oral montelukast (group B) by inhalation chamber over 12 weeks. All clinical variables by fill out a questionnaire, pulmonary functions (PEF, FEV1) were recorded at the baseline, 6, and 12 weeks. Results: The results showed that adding Montelukast to inhaled Budesonide improves the FEV1, PEF values, and quality of life (decrease the use of beta 2 agonists, the frequency of asthma symptoms, the night symptoms, and the defines activate with a significant difference. Conclusion: This study suggests that there is a therapeutic benefit of adding Montelukast to inhaled Budesonide in the treatment of patients with mild and moderate severity of persistent asthma

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