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COMPARISON BETWEEN THE EFFICACY OF NEBULIZED MAGNESIUM SULFATE WITH ADRENALINE VERSUS ADRENALINE ALONE IN THE TREATMENT OF ACUTE BRONCHIOLITIS
*Mervat Gassan Shreiba, Ghazal Dib and Amal Al-hakim
Background: Acute bronchiolitis is the most common lower respiratory disease, requiring hospitalization in children under the age of two years. Several therapeutic approaches have been proposed to treat acute bronchiolitis, but so far supportive treatment remains the primary. ? Objective: The current study aims to evaluate the efficacy of magnesium sulfate and epinephrine nebulization in reducing the duration of hospitalization and improving the symptoms of acute respiratory distress caused by acute bronchiolitis in comparison with adrenaline nebulization. ? Methods: In a randomized controlled trials study that included 130 patients with acute bronchiolitis with moderate and severe respiratory distress (RDAI greater or equal to 5) aged between 3 months and 2 years, who were admitted to the pediatric department in Tishreen University Hospital at the period between January 2020 to January 2021. The patients were divided into two groups, each containing 65 patients, according to the randomization schedule, one of which was treated with adrenaline nebulization and the other with magnesium sulfate combined with adrenaline nebulization, with the patients being monitored and the development of the RDAI indicator recorded at admission to discharge. ? Results: The results showed an improvement in the duration of hospitalization and RDAI in patients with magnesium sulfate and adrenaline nebulization compared with adrenaline nebulization from the second day of treatment, with fewer side effects resulting from the treatment. ? Conclusion: The current study confirmed the possibility of using magnesium sulfate with adrenaline nebulization to reduce the duration of hospitalization and to improve and improve the RDAI in children with acute bronchiolitis.[Full Text Article]