WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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Indexing

Abstract

THE VALUE OF MEASURING ALPHA-FETOPROTEIN IN PATIENTS WITH GASTRIC CANCER

Dr. Haydar Abd Al-Kader Al-Jawadi*

ABSTRACT

Gastric cancers are among the most frequently diagnosed cancer in the world. Advances in preclinical diagnostic methods have been resulted in dramatic changes in determining the survival of patients. Evaluation of serum level of tumor markers is one of these methods. Tumor markers are substances that can often be detected in higher than normal amounts in blood, urine, or body tissues of some patients with certain types of cancer. In this study the samples were collected from two groups; the first group consisted of 30 healthy volunteers (14 female and 16 male) aged between 20-60 years (45.47 ± 10.87), the second group consisted of 16 patients with gastric cancer, aged between 45-70 years (61.75 ± 9.32) were classified according to presence of metastasis (4 cases), regional lymph nodes involvement (4 cases), patients with distant metastasis (5 cases) and lastly patients with recurrence after previous operation (3 cases). Histologically they were classified into patients with well differentiated adenocarcinoma (10 cases), and those with poorly differentiated adenocarcinoma (6 cases). AFP measured for both healthy and patients’ groups and give a significant difference at p< 0.01 for serum level of AFP as mean ± SD between control and patients with gastric cancer. The sensitivity of AFP in patients with gastric cancer in all studied subjects was 43.75% which increased to 58.3% in patients with metastasis only. The mean value of serum AFP level was shown to be higher in patients with metastasis than those without metastasis, this level is independent to the site of metastasis. The difference in AFP level showed a significant difference at p<0.05 between them, with a higher level of AFP being detected in patients with liver metastasis. In comparing the results of AFP in different histological types of gastric cancer, the results show that patients with undifferentiated carcinoma did not have significant lower level of AFP than those with more differentiated cancer.

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