WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

Impact Factor  :  5.464

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    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

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    Venue: FCT Education Resource Center, Abuja-Nigeria

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Indexing

Abstract

PROGNOSTIC VALUE OF SERUM LDH AT DIAGNOSIS IN PATIENTS WITH MULTIPLE MYELOMA

Hashem Abdulaziz Hashem*, Firas Hussein and Mohammad Imad Khaiat

ABSTRACT

Background: Multiple myeloma (MM) is a malignant disorder of clonal plasma cells. A number of biological factors influence the evolution of patients with MM. Objective: the present study aims to evaluate the prognostic value of serum lactate dehydrogenase (LDH) at diagnosis in terms of survival of patients with MM and response to treatment. Materials and Methods: This is prognostic study conducted in the Department of Oncology in Tishreen University Hospital –Lattakia- Syria between January 2006 and January 2016. Patients who newly diagnosed with MM were included in the study. Results: A total of 120 patients with MM were included in the study. The median age was 60.5 years and 55% were men. Arate of 48.3% of patients were in stage II, and 72.5% of cases were secreted of IgG. The response to therapy was complete in 16 % of patients with elevated level of LDH versus 44.3% in normal LDH group (p<0.05), and refractory to therapy was more frequently in elevated LDH group (36% vs. 2.9%, p:0.001). Median overall survival(OS), progression –free survival(PFS) were 65.3±32.9 ,36.3±21.5 months respectively in normal LDH group versus 36.7±20.4 , 16.06±17.4 months respectively in elevated LDH group (p:0.0001). High level of LDH, creatinine, and stage III were independent adverse prognostic parameters for both OS and PFS (p<0.05). Conclusion: High level of LDH is a negative prognostic factor in evolution of MM patients, adversely influencing therapeutic response rates and reducing the survival of patients with MM.

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