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Abstract
A REVIEW ON HYDROGEL DRUG DELIVERY SYSTEM
Shoaeba Shaikh*, Ummehani Kallawala, Misbah Sheikh, Sharav Desai, Hitesh Jain and D. B. Meshram
ABSTRACT
Conventional drug administration often requires high dosages or repeated administration to stimulate a therapeutic effect, which can lower overall efficacy and patient compliance, and result in severe side effects and even toxicity. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Hydrogels as a drug delivery system have been used in many branches of medicine, including cardiology, oncology, immunology, wound healing, and pain management. Due to their high water content, these gels resemble natural living tissue more than any other type of synthetic biomaterial. Chemical initiator initiates the polymerization reaction. Some applications are used of hydrogels in human body. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can be used as biosensors as well as drug delivery systems.
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