WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
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ISSN 2457-0400

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Indexing

Abstract

SENSITIVITY AND SPECIFICITY OF FECAL CALPROTECTIN IN DIAGNOSING INFLAMMATORY BOWEL DISEASE

Hussein Haj Ahmad*, Hassan Zaizafoun and Daad Daghman

ABSTRACT

Background and purpose: This study aims to find out the diagnostic value of fecal calprotectin in inflammatory bowel disease and to assess the sensitivity and specificity of this test with a brief analysis of clinical symptoms and laboratory analyzes of suspected patients. Methods and patients: This study was conducted at Tishreen University Hospital between the end of 2018 and the beginning of 2020, and included 60 patients who had a suspicion of the presence of inflammatory bowel disease, where demographic characteristics (age, gender), clinical and laboratory data were determined, and a qualitative calprotectin investigation was conducted. patients were then referred for gastroscopy and tissue biopsies as required, to obtain a final diagnosis. Results: The study included (33 male, 27 female) whose ages ranged between 16 and 80 years old. the most important clinical presentation they had was abdominal pain in 82% of them and diarrhea in all its forms 68.3% of all patients, and laboratory results showed an increase in the value of CRP at 63.3% Of them with increase in ESR in 33.3% of all cases, the incidence of disease in the total sample was 70%, i.e. 42 patients of them, while 18 patients remained without the disease (30% of the sample). the sensitivity of calprotectin in detecting the disease was 88% and the specificity 89%, while the positive predictive value was 94.87%, the negative predictive value was 76.19%, and the overall accuracy of the test was 88.33%. Conclusions: Fecal calprotectin is an important, and non-invasive test that has good sensitivity and specificity in orienting towards the diagnosis of inflammatory bowel disease, as the test showed reliability in the ability to distinguish the presence of an inflammatory injury in the intestinal mucosa.

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