WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , 

ISSN 2457-0400

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Indexing

Abstract

THE ASSOCIATION BETWEEN ADVANCED MATERNAL AGE AND STILLBIRTH RISK

Amneh Fadl*, Ahmad Youssef and Thora Naissa

ABSTRACT

Background: Pregnancy at advanced maternal age (AMA) has become more common over the last decades. The association between adverse perinatal outcomes and AMA has been a matter of controversy in several studies. Objective: the aim of the study is to investigate the impact of maternal age on stillbirth risk of singleton pregnancies without fetal defects. Materials and Methods: This is prospective study conducted in the Department of Obstetrics and Gynaecology in Tishreen University Hospital –Lattakia- Syria from November 2019 to November 2020. All pregnant women who aged 20 to 49 years were included in the study. Results: A total of 1560 pregnant women were included in the study, Mean maternal age was 28.7 ± 6.2 years with 254(16.3%) women in the group of age 35-39 years and 81(5.2%) women? 40 years, stillbirths were recorded in 32(2%) cases at a rate 20.5 per 1000 delivery. Maternal age was an independent risk factor for stillbirth, compared to the reference, group age ? 40 years had a significantly higher risk of stillbirth than group of age 35-39 years (HR: 2.73;95% CI:0.64-11.7 vs HR:2.01;95% CI:0.63-6.4, P:0.04). Other risk factors of stillbirth were: Smoking (HR: 2.46; 95% CI:1.12-5.4, P:0.02), nulliparous women (HR:3.61;95% CI:1.6-8,P:0.001), pre-existing hypertension(HR: 2.87 ;95%CI:1.2-6.49,P:0.01)and pre-existing diabetes mellitus (HR: 4.6 ;95% CI:1.9-11,P:0.0005). The risk for stillbirth was higher in older nulliparous women than older multiparous. Conclusion: AMA is an independent risk factor for stillbirth. Therefore, it is better for health care providers to counsel couples who seek to have the first child at advanced age about the risks of pregnancy in this period.

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