WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Galleh P. R., Oti B. V.*, Olayinka B. O. and Tytler B. A.

ABSTRACT

One of the reasons for the chronic nature of some infections caused by opportunistic pathogen such as Pseudomonas aeruginosa is the ability of it to form biofilms. This study assessed the anti-adhesive and anti-biofilm activities of leaf extracts from Ficus platyphylla, Jatropha curcas and Anthocleista vogelii on biofilms formed by clinical isolates of Pseudomonas aeruginosa using standard microbiological techniques. Out of the 59 isolates tested, 35 (59.32%) were biofilm positive. Methanolic extract of Jatropha curcas has the highest percentage of adhesion inhibition 29 (82.86%) while ethanolic extract of F. platyphylla recorded the lowest percentage of adhesion inhibition 16 (45.75%) at the sub-inhibitory concentrations (0.625-1.88mg/ml) tested. The highest percentage inhibition of pre-formed biofilm was with methanolic extract of J. curcas 15 (42.86%) followed by ethanolic extract 12 (34.29%) and the lowest was with the methanolic extract of F. platyphylla 10 (28.57%). Methanolic extract of Jatropha curcas is the most active against the biofilm producing Pseudomonas aeruginosa clinical isolates. The anti-adhesion potentials showed by these plant extracts may provide a complementary medication for biofilm associated infections and damages to industrial surfaces associated with biofilm formation.

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