WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals
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Indexing

Abstract

FORMULATION AND EVALUATION OF DENTAL GEL CONTAINING CLOVE OIL FOR THE TREATMENT OF PERIODONTAL DISEASE- A REVIEW

Prashant Kumar Katiyar*, Dr. Smita Takerkhade, Madhavi Ashika Lahu, Masne Mangala Ambanna, Mhatre Prajkta Bhagvan, Mishra Mithilesh Kumar Rakesh, Mishra Saurabh Mangalprasad

ABSTRACT

The study was aimed to formulate and evaluate dental gel containing clove oil as the chief constituent for the treatment of periodontitis. Clove oil has a wide spectrum of antibacterial activity against a number of periodontal pathogens, hence it is selected for the treatment of periodontitis. Clove oil gel is formulated by using carbopol 934 as gelling agent, clove oil as medicinal agent, polyethylene glycol as co-solvent, methyl paraben and propyl paraben as preservative and required quantity of distilled water as vehicle. The periodontal disease commonly refers to inflammatory diseases that are plaque induced i.e. gingivitis and periodontitis. Gingivitis, the moderate stage of disease caused by an accumulation of supragingival plaque and characterized by swelling, light bleeding and redness of the marginal gingival. Gingivitis is associated with a change in the microflora, shifting from a Gram-positive anaerobic flora to a more Gram negative one. Periodontitis, a more severe stage of periodontal disease, results in the resorption of the alveolar bone and detachment of the periodontal ligament supporting tooth. This study was aimed to formulate dental gel containing clove oil for the treatment of periodontal diseases and then was evaluated for their physicochemical properties including drug content, spreadability, extrude ability, in-vitro antibacterial activity.

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