WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

*Anandkumar S., Akila V., Aksa Ann Joy, Akshayasre G. and Aleena Baiju Varghese

ABSTRACT

H. pylorus is the main cause of various gastric diseases such as peptic ulcer, duodenal ulcer, and gastric cancer. Cardiovascular diseases like congestive heart disease, metabolic disorders like DM, lipid metabolism disorders like atherosclerosis are also caused by H. pylori. H. pylori infection causes secretion imbalance of pro-inflammatory cytokines and CRPs, angiotensinogen, leptin hormone, and free fatty acids, however, the exact association of metabolic syndrome and Helicobacter pylori infection is not clear. The main mechanism of a metabolic syndrome caused by H. pylori is that the bacterium causes a disturbance in the host’s immunological response which leads to the production of proteins such as CagA, VacA, BabA, and SabA. This mechanism is seen in the association of H. pylori infection and gastrointestinal diseases, diabetes mellitus, lipid profile changes as well as cardiovascular diseases. The inflammation and production of inflammatory cytokines along with different hormonal imbalances is caused by the bacterium. Since there are no specific treatment guidelines for the management of metabolic syndrome associated with HP infection, total eradication of the infection is the goal to be achieved done by the standard triple therapy. H. pylori eradication must be done as early as possible for the management of gastro- and extra gastrointestinal diseases caused by the bacterium.