WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Jiyan Qasem*, Ibrahim Suliman and Firas Hussein

ABSTRACT

Background: Patients with sickle cell disease (SCD) are at increased risk of serious morbidity and mortality. Renal abnormalities in SCD are well known but renal involvement in Syrian patients with SCD has not been studied. Aim: We sought to identify the renal manifestations of sickle cell anemia among patients attending Tishreen University Hospital in Lattakia. Materials and Methods: This descriptive observational study included 76 patients (42 males, 34 females) diagnosed with sickle cell anemia confirmed by hemoglobin electrophoresis, and followed at Tishreen University Hospital in Lattakia, during the period between 2019 - 2020. The glomerular filtration rate was estimated (eGFR) using the ‘modification of diet in renal disease’ (MDRD) formula. All patients underwent evaluation by urine examination to detect hematuria, and 24- hour urine collection to measure to quantitate proteinuria. We constructed a multivariate logistic regression model to assess the association between hydroxyurea and proteinuria. Results: The renal manifestations of sickle cell anemia were as follows: glomerular hyperfiltration (9.2%), impaired renal function (31.6%), proteinuria (39.5%), and hematuria (19.7%). Patients with impaired renal function had a greater mean age and a higher prevalence of proteinuria compared with patients with normal renal function. A statistically significant inverse linear relationship was found between age and eGFR values (r = -0.547, p