News & Updation
Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
Download Article : Click here
THE PROGNOSTIC VALUE OF PERIPHERAL BLOOD ABSOLUTE LYMPHOCYTE TO MONOCYTE RATIO AT DIAGNOSIS IN HODGKIN’S LYMPHOMA PATIENTS
Oula Yousef Nfelah*, Tagrid Kaddar and Firas Hussein
Determination of prognostic factors in Hodgkin’s Lymphoma patients plays an important role in reducing intensive chemotherapy, decreasing economic costs, and improving the outcome of the patients. We conducted this study to determine the prognostic value of [lymphocyte/monocyte ratio (LMR)] in Classical Hodgkin’s Lymphoma patients (cHL) [trying to establish a relationship between it, overall survival (OS) & progression free survival (PFS)]. Also, we wanted to study the relationship between LMR and other variables such as age, sex, histological type, white blood cells, absolute lymphocyte count, absolute monocyte count, hemoglobin, serum albumin, Ann Arbor Staging, B-Syptoms, early or advanced stages, bulky mediastinal mass, type of primary treatment if chemotherapy alone or radiochemotherapy and the effect of these variables on OS and PFS. A retrospective study included 242 patients with cHL admitted to the center of radiochemotherapy in Tishreen University Hospital in Lattakia from January 2011 to December 2015. We monitored the patients until 1st September 2020. An LMR at diagnosis of 2.9 or more was the best cut-off value for survival. In univariate analysis, patients with LMR < 2.9 had inferior OS and PFS. LMR had an important prognostic value in patients with limited or advanced stages. In multivariate analysis, LMR was an independent prognostic factor for survival and to predict clinical outcomes in patients with classical Hodgkin’s lymphoma. In conclusion, LMR provides a simple model to assess clinical outcomes in cHL.[Full Text Article]