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Abstract
REPURPOSING BCG VACCINE FOR COVID19 IMMUNITY
Mrudula Phadke* and Sujata Saunik
ABSTRACT
Covid 19 pandemic has created havoc in the world. As on 20th September 2020,the virus has reached 216 countries affecting nearly 31711237 people and 960826 have lost their lives. Various modes of treatment with the use of Hydroxychloroquine, Doxycycline, Ivermectin, VitaminC, Zinc, Favipiravir, Remdesivir, Dexamethasone, Itolizumab, inhahed interleukins and others are being tried with varying degrees of success. Randomized clinical trials are being undertaken in many countries. Vaccines against Covid19 are in different phases of clinical trials and development. Scientists are also attempting to repurpose other vaccines that may offer protection against Covid 19. BCG is one such vaccine, available in the armamentarium for use. Preliminary reports suggest that BCG will offer nonspecific heterologous protection to decrease the occurrence of Corona virus SARS CoV2 infection or may help in decreasing the severity of the disease. This effect is likely to be mediated through ‘trained immunity’ offered by cells responsible for innate immunity.
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