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DIASTOLIC DYSFUNCTION IN TYPE II DIABETES AND ITS CORRELATION WITH GLYCOSYLATED HAEMOGLOBIN
Tarfa Abed, MD*, Akram Jahjah, PHD and Munif Al Meri, PHD
Background: The alteration of left ventricular diastolic function is considered to be one of the earliest ultrasonographic signs of diabetic cardiomyopathy, which is a well-known chronic complication of diabetes mellitus. glycosylated haemoglobin (HBA1c) is the standard marker for monitoring the control of glycemic status, although biological studies indicate that HBA1c has a negative effect on the cardiovascular system, this effect has not been sufficiently studied so far. Aim: Highlight the role of HBA1c as not only a marker, but also a risk factor for diabetic cardiomyopathy. Materials and Methods: in this case-control study, a total of 80 patients with type2 diabetes aged between 40-70 years, were selected from Tishreen University Hospital and been included in the case group and been compared with 80 non diabetic participants as a control group, the two groups were matched in terms of: age, gender, blood pressure and BMI, the two groups were scrutinized for Doppler echocardiography, ECG, stress ecg, both groups underwent an objective exam, full biochemistry profile, and Blood pressure measurement. HBA1c analysis was performed for the case group. Results: in the case group Diastolic dysfunction of left ventricle was observed in 66 patients out of 80 (82.5%), the grades of Diastolic dysfunction were 33(50%) for grade I, 22(33.3%) for grade II, 11(16.7%) for grade III, 16(20%) patients of the case group had HBA1c <7,19(23.75%) with HBA1c between 7.1-8, 11(13.75%) with HBA1c between 8.1-9, 20(25%) with HBA1c >9, and 14(17.5%) without diastolic dysfunction all of them had HBA1c <7. in the control group Diastolic dysfunction of left ventricle was observed in 30 participants out of 80 (37.5%), the grades of Diastolic dysfunction grades were 28(93.3%) for grade I, 2 (6.7%) for grade II, 0% for grade III. Conclusion: Diastolic dysfunction of left ventricle is a common finding in patients with type 2 diabetes, elevated levels of HBA1c increase the risk of developing Diastolic dysfunction and with higher grades, Hence, it is a risk factor for diabetic cardiopathy.[Full Text Article]