WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Kourosh Karimi Yarandi, Ahmad Pourrashidi*, Mohammad Hosseinzade, Hedieh Moradi Tabriz, Mohammad Shirani and Abbas Amirjamshidi

ABSTRACT

Background: Novel coronavirus disease 2019 (COVID-19) is a pandemic infection that appeared in December 2019, in Wuhan, China. It has been considered as a multi-systemic disease that could involve central nervous system. We intend to report a case of fulminant primary CNS lymphoma (PCNL) misdiagnosed as COVID-19 infection and led to a delay in treatment. Case presentation: A 75-year-old female was admitted in our hospital due to altered mental status and mild fever. She had a history of tiredness, headache, and low-grade fever presented within two weeks. Her chest CT scan was apparently compatible with pulmonary involvement seen in COVID-19 and she was treated accordingly. Brain CT scan and MRI showed periventricular hyper-dense changes, diffuse brain edema and periventricular enhancing lesions. CSF analysis and brain biopsy confirmed the diagnosis of PCNL. Conclusions: It can be concluded that the in the outbreak of COVID-19 some manifestations of other diseases can be confused and assumed as the signs and symptoms of the pandemic disease and overdiagnosis of COVID-19 may result in missing the others. Although this infection has several faces with the ability to involve multiple organs, it always should be differentiated from the other possible illnesses to prevent devastating complications.

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