WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Shreya Parkar*, Rutuja Sawant, Prajakta Kegade and Akshay Gade

ABSTRACT

Intranasal drug delivery can be visualized as the promising route for the administration of drugs as it has the potential to overcome some major limitations associated with other routes. It is one of the promising approach for the systemic delivery of drugs because concentration time profile of drugs achieved after nasal administration is often similar to that obtained after intravenous administration. Nasal administration has a drawback of poor retention time which is overcome by novel drug delivery i.e. In-situ gelling system. In-situ gelling system is a polymeric solution which can be administered in solution form, and it undergoes sol-gel phase transition into a viscoelastic gel upon exposure to physiological conditions (e.g. pH, temperature and ionic concentration). This system also has a great impact in the treatment of neurological disorders. Neurodegenerative diseases are becoming prevalent as the population ages. Preclinical reports from several researchers have proven that the delivery to the brain via the nose-to-brain route using in situ gels holds great promise. The ‘in situ gel’ system has become one of the best novel drug delivery systems by its special characteristic feature of ‘Sol to Gel’ transition. The treatment of neurological disorders require the delivery of therapeutics to the brain in appropriate amounts to elicit a pharmacological response. Nose-to-Brain delivery has emerged as a powerful strategy to overcome the BBB and deliver drugs to the brain. The present review highlights anatomy of nose, nose to brain delivery and its advances in the treatment of neurological disorders.

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