WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

ISSN 2457-0400

Impact Factor  :  5.464

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    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

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    Venue: FCT Education Resource Center, Abuja-Nigeria

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Indexing

Abstract

THE ROLE OF MEAN PLATELET VOLUME IN THE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Dima Fatahi*, Malek Hejazie and Firas Hussain

ABSTRACT

Background: Studies have supported the correlation between mean platelet volume and COPD. However, there are limited data on the relationship between COPD exacerbation and mean platelet volume. Aim: This study was aimed to evaluate the mean platelet volume trend in patients with COPD exacerbation. Materials and Methods: This was a prospective study in which 80 patients with acute COPD exacerbation were enrolled at Tishreen University Hospital, Lattakia during the period between 2019 - 2020 . The levels of mean platelet volume, C-reactive protein, complete blood count, and percent of- predicted FEV1 were measured in subjects at admission (exacerbation period) and after 3 months (stable period). Results: Subjects in the exacerbation period had significantly higher levels of C-reactive protein (P<0.0001), white blood cell count (P<0.0001) and percentage of neutrophils (P<0.0001) and lower percent-of-predicted FEV1 than in the stable period (P<0.0001). Mean platelet volume levels were significantly decreased in the exacerbation period(P<0.0001). Mean platelet volume levels correlated negative significantly with increase of C-reactive protein level in the exacerbation period (r = - 0.342, p<0.001) and in the stable period (r = -0.168, p=0.0347). Conclusion: Mean platelet volume may be an inflammatory marker in exacerbation of COPD.

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