WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Review Journal for Medical Science and Pharma Professionals

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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Indexing

  Indexing

  • Google Scholar
  • Index Copernicus
  • SOCOLAR, China
  • Research Bible, Fuchu, Tokyo. JAPAN
  • Cosmos Impact Factor
  • Scientific Indexing Services (SIS)
  • UDLedge Science Citation Index
  • International Impact Factor Services
  • International Society for Research Activity (ISRA) Journal Impact Factor (JIF)
  • IFSIJ Measure of Journal Quality
  • Scientific Journal Impact Factor (SJIF)
  • International Scientific Indexing, UAE (ISI) (Under Process)
  • International Impact Factor Services (IIFS)
  • Web of Science Group (Under Process)
  • Directory of Research Journals Indexing
  • Scholar Article Journal Index (SAJI)
  • International Scientific Indexing ( ISI )
  • Academia
  • Scope Database

Abstract

CIRCULATING CD34-POSITIVE STEM CELLS IN PERIPHERAL BLOOD OF PATIENTS WITH HODGKIN LYMPHOMA

Hala Ahmad*, Ghassan AlMassarani, Adnan Ikhtear, Haissam Yazigi, Reem Nadra, Suzan Samra

ABSTRACT

Hematopoietic stem cells are characterized by the properties of self-renewal and multi-lineage differentiation. Bone marrow residing stem cells are mobilized from their BM niches into peripheral blood in many pathological situations including tissue injury and systemic inflammation. Although the role of non-mutated normal stem cells in cancer progression is still under debate. Circulating normal peripheral blood stem cells may play an important role in the vascularization of the growing tumor. We assessed CD34+ cells from the peripheral blood of 15 patients with de novo Hodgkin Lymphoma using flowcytometry. We found that CD34+ cell counts and CD34+ cell percentages were significantly higher in Lymphoma patients at diagnosis than in controls. After the induction of chemotherapy, CD34+ cell count and CD34+ cell percentage levels were significantly decreased in Lymphoma patients compared with their levels at diagnosis. The mean baseline levels of CD34+ cell count and CD34+ cell percentage in Lymphoma patients who achieved complete response were significantly lower than in those who did not achieve it in response to induction treatment. We concluded that the number and percentage of circulating CD34+ cells in peripheral blood in cancer patients depend on the tumor type, and can be used as a prognostic value for complete response.

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