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EVALUATION OF CRP LEVEL AS MONITORING TOOL FOR PATIENT WITH FACIAL SPACE INFECTION
Dr. Sami Faisal Jamdar*, Dr. Aaminah Fatima Jamdar and Zidan Muead Alanazi
Background and Aim Despite greatly improved health services available in present era, severe odontogenic infections still remains leading cause of morbidity and mortality. Thus close monitoring of such patients becomes a necessity and efficient monitoring tools are required for the same. The objectives to assess efficacy of CRP levels as monitoring tools for determining severity of infections, severity of malnutrition and nutritional status, length of hospital stay, and efficacy of treatment regime. Materials & Methods: The blood samples of the patients were taken on Day 0 and Day 5 for measuring serum levels of the markers. Simultaneously clinical parameters like swelling size, mouth opening, pain etc. were also recorded on Day 0 and Day 5. The appropriate treatment was given to each patient. Analyses were done to find correlation between markers and clinical parameters of odontogenic infections using regression and paired t- test. Results: The statistical analysis found strong correlation between lab values of markers and clinical parameters used to measure severity of infection. The analysis also proved that values of markers significantly changed and moved towards normal as the condition of patient improved with effective treatment. Similarly, CRP was also a significant predictor for hospital stay (P<0.001) and 40.11% of the variation in X hospital stay was explained by CRP. (P<0.001) Conclusion: The findings of this prospective analysis indicate C-reactive protein are effective markers for determining severity of infection, efficacy of treatment regime and length of hospital stay for patients with fascial space infections of odontogenic origin. The duration of antibiotic usage, need for intensive care, and use of additional nutritional supplements becomes more rationale if these markers are incorporated in the clinical decisions. Thus we conclude that CRP should be incorporated as monitoring tools for patients with fascial space infections.[Full Text Article]