WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

ISSN 2457-0400

Impact Factor  :  5.464

News & Updation

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in WJAHR coming Issue.

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • 6th International Conference on Human and Soci

    Venue:FCT Education Resource Center, Abuja- Nigeria                                        September 22-24, 2019

  • WJAHR New Impact Factor

    Its our Pleasure to Inform you that WJAHR Impact Factor has been increased from  4.897 to 5.464 due to high quality Publication at International Level

  • .

    6th INTERNATIONAL CONFERENCE ON EDUCATIONAL TECHNOLOGY AND CURRICULUM STUDIES(ICETC2019) 

     

    Venue: FCT Education Resource Center, Abuja-Nigeria

    September 22-24, 2019

  • WJAHR MAY ISSUE PUBLISHED

    MAY 2020 Issue has been successfully launched on 1 May 2020.

  • New Issue Published

    Its Our pleasure to inform you that, WJAHR 1 May 2020 Issue has been Published, Kindly check it on http://www.wjahr.com/home/current_issues

Best Paper Awards

World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.

Best Article of current issue

Download Article : Click here

Indexing

Abstract

EFFECTS OF NICOTINE AND CHROMIUM (VI) CO-EXPOSURE ON THE FUNCTIONAL STATUS OF LIVER IN MALE ALBINO RAT

Amit Nandi, Soumita Dey, Surachita Das, Sandip Kumar Sinha, Sankar Kumar Dey

ABSTRACT

Background: Nicotine is one of the major constituents of different types of smoking and is the more toxic part also. Thirty metals including chromium and some chromium compounds have been detected in tobacco smoke are causally associated with cancer in humans. Objective: In the present investigation, we evaluate the individual and combined effect of nicotine and chromium (VI) on the functional status of liver in animal. Materials and Methods: In this study, a group of male Wistar rats (80-100 g) were induced by intraperitonial injection of vehicle (0.9% NaCl), nicotine tartrate (0.2 mg / 100 g body weight / day), K2Cr2O7 (0.8 mg / 100 g body weight / day) and, combined exposure of nicotine tartrate and K2Cr2O7 at an interval of six hours for a period of 28 days. After the period of treatment the blood samples were collected to measure the liver function test related parameters. Results: It was showed that individual and combined exposure of nicotine and chromium (VI) marked increased the activities of ALP, AST, ALT, LDH and the levels of bilirubins were decreased. On the other hand, there were no significant alterations were observed in the level of total protein and albumin in response to individual and combined exposure of nicotine and chromium. Conclusion: The present study suggests that nicotine and chromium exhibited significant changes during individual exposure whereas co-exposure showed a marked alteration of the functional status of liver in male albino rats.

[Full Text Article]