WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Amit Nandi, Soumita Dey, Surachita Das, Sandip Kumar Sinha, Sankar Kumar Dey

ABSTRACT

Background: Nicotine is one of the major constituents of different types of smoking and is the more toxic part also. Thirty metals including chromium and some chromium compounds have been detected in tobacco smoke are causally associated with cancer in humans. Objective: In the present investigation, we evaluate the individual and combined effect of nicotine and chromium (VI) on the functional status of liver in animal. Materials and Methods: In this study, a group of male Wistar rats (80-100 g) were induced by intraperitonial injection of vehicle (0.9% NaCl), nicotine tartrate (0.2 mg / 100 g body weight / day), K2Cr2O7 (0.8 mg / 100 g body weight / day) and, combined exposure of nicotine tartrate and K2Cr2O7 at an interval of six hours for a period of 28 days. After the period of treatment the blood samples were collected to measure the liver function test related parameters. Results: It was showed that individual and combined exposure of nicotine and chromium (VI) marked increased the activities of ALP, AST, ALT, LDH and the levels of bilirubins were decreased. On the other hand, there were no significant alterations were observed in the level of total protein and albumin in response to individual and combined exposure of nicotine and chromium. Conclusion: The present study suggests that nicotine and chromium exhibited significant changes during individual exposure whereas co-exposure showed a marked alteration of the functional status of liver in male albino rats.

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