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AGE-RELATED HAEMATOLOGICAL VARIATIONS IN RELATION TO SERUM ERYTHROPOIETIN LEVELS OF INDIVIDUALS IN ELELE, RIVERS STATE
*Nwuzor Miriam Daberechi, Okoroiwu Ijeoma Leticia and Obeagu Emmanuel Ifeanyi
Age –Related Haematological Variations in relation to Serum Erythropoietin Levels of Individuals in Elele, Rivers State was carried out amongst children, adolescents and geriatrics at Madonna University Teaching Hospital Elele, Rivers State. A total of 116 Subjects were recruited for the study. It comprised 20 males and 16 females for children, 20 males and 20 females for adolescent’s group, 20 males and 20 females for geriatrics. Erythropoietin level was determined using Enzyme Linked Immuno- Sorbent Assay (ELISA), packed cell volume, haemoglobin level; total white blood cell count, differential white blood cell count, platelet count and red blood cell count were determined using standard method. Results from children showed statistical increase in neutrophil and lymphocytes in male children while serum Erythropoietin and other haematological parameters were statistically insignificant (P>0.05).Children showed significant correlation of serum erythropoietin which was negative for packed cell volume and haemoglobin in children. On the adolescents category, serum erythropoietin increased statistically on the females while packed cell volume, haemoglobin level, total white blood cell counts showed statistical increase in males (P<0.05).Other haematological parameters on the adolescents were statistically insignificant. Correlation of serum erythropoietin with other haematological parameters in adolescents showed significant negative correlation with packed cell volume and haemoglobin level while it showed significant positive correlation with red blood cell count.Geriatrics result displayed that serum erythropoietin,platelet count and neutrophil had statistical increase in the female while packed cell volume, haemoglobin level and lymphocytes of geriatric males showed statistical increase(P<0.05). Correlation of serum erythropoietin with some haematological parameters of geriatrics showed significant negative correlation of serum erythropoietin with packed cell volume and haemoglobin while it was positive for total white blood cell count and neutrophils. In conclusion, serum erythropoietin increases as packed cell volume and Hb decreases in children, adolescents and geriatrics. Among other haematological parametres, packed cell volume and haemoglobin increases at a higher rate in adolescent stage than other stages of life (childhood and geriatric stage). Serum erythropoietin has negative correlation with packed cell volume and haemoglobin in children, adolescents and geriatrics while it has positive correlation with red blood cell in adolescents.[Full Text Article]