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Best Paper Awards
World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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CALCIPHYLAXIS IN CHRONIC RENAL FAILURE: ABOUT ONE CASE
Ayoub Khanoussi*, Fatima Nachite, Abderahim El Naderi, Hanane Rais, Wafaa Fadili and Inas Laouad
Summary: Calciphylaxis or uremic and calcifying arteriolopathy is a rare, life-threatening condition, mainly affecting dialysis patients or patients with renal insufficiency. It is characterized by the rapid onset of infiltrated, inflammatory, purplish and livid patches of skin, resulting in deepening and necrotic ulcerations, surrounded by livedo purpuricus, sitting on the trunk, in the adipose areas, or on the limbs. Cutaneous histology reveals calcifications of the media of the deep dermal and hypodermal arterioles, intimal hyperplasia and necrotic panniculitis. Images of thrombosis and extravascular calcifications are also reported. The treatment combines several simultaneous strategies aimed at decreasing the phosphocalcic product, dissociating and removing calcium deposits, clearing necrosis and avoiding potentially fatal septic complications. We report an observation of a histologically confirmed calciphylaxis and review the pathogenesis, clinical, biological, therapeutic and evolutionary characteristics of this complication in the literature.[Full Text Article]