WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

An International Peer Review Journal for Medical Science and Pharma Professionals
World Journal of Advance Healthcare Research (WJAHR) has indexed with various reputed international bodies like : Google Scholar , Index Copernicus , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , Cosmos Impact Factor , Scientific Indexing Services (SIS) , UDLedge Science Citation Index , International Impact Factor Services , International Society for Research Activity (ISRA) Journal Impact Factor (JIF) , IFSIJ Measure of Journal Quality , Scientific Journal Impact Factor (SJIF) , International Scientific Indexing, UAE (ISI) (Under Process) , International Impact Factor Services (IIFS) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , 

ISSN 2457-0400

Impact Factor  :  5.464

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Indexing

Abstract

CALCIPHYLAXIS IN CHRONIC RENAL FAILURE: ABOUT ONE CASE

Ayoub Khanoussi*, Fatima Nachite, Abderahim El Naderi, Hanane Rais, Wafaa Fadili and Inas Laouad

ABSTRACT

Summary: Calciphylaxis or uremic and calcifying arteriolopathy is a rare, life-threatening condition, mainly affecting dialysis patients or patients with renal insufficiency. It is characterized by the rapid onset of infiltrated, inflammatory, purplish and livid patches of skin, resulting in deepening and necrotic ulcerations, surrounded by livedo purpuricus, sitting on the trunk, in the adipose areas, or on the limbs. Cutaneous histology reveals calcifications of the media of the deep dermal and hypodermal arterioles, intimal hyperplasia and necrotic panniculitis. Images of thrombosis and extravascular calcifications are also reported. The treatment combines several simultaneous strategies aimed at decreasing the phosphocalcic product, dissociating and removing calcium deposits, clearing necrosis and avoiding potentially fatal septic complications. We report an observation of a histologically confirmed calciphylaxis and review the pathogenesis, clinical, biological, therapeutic and evolutionary characteristics of this complication in the literature.

[Full Text Article]