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World Journal of Advance Healthcare Research (WJAHR)Honored the authors with best paper award, monthly based on the innovation of research work. Best paper will be selected by our expert panel.
Best Article of current issue
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EVALUATION OF NON-INVASIVE MARKERS OF FIBROSIS AND THEIR CORRELATION WITH THE VIRAL LOAD IN SUBJECTS WITH HEPATITIS B VIRUS IN NNEWI
Obiomah Chinwe Favour*, Amilo Grace I., Obeagu Emmanuel Ifeanyi and Vincent C. C. N.
Hepatitis B is an infectious disease of great public health importance. Nigeria is one of the countries with the highest incidence of Hepatitis B Virus (HBV) infection worldwide. However, the accessibility and affordability of HBV DNA quantification (viral load) assay which is the key laboratory test for therapy initiation, and monitoring is a challenge to HBV management. This study was designed to evaluate the non-invasive markers of fibrosis and their correlation with the viral load in subjects with hepatis B virus in Nnewi. Cross sectional study design was used with a total of 264 subjects comprising of 88 HBsAg seropositive treatment naïve subjects, 88 HBsAg seropositive subjects on antiviral therapy as case subjects and 88 age-matched apparently healthy HBsAg seronegative individuals were recruited as control subjects. Hepatitis B virus DNA assay was performed using real time PCR technique, Hepatitis C Virus assay, Human Immunodeficiency Virus testing, Gamma glutamyl transferase, Aspartate transaminase, Alanine transaminase tests were determined using spectrophotometric methods. Non-invasive markers of fibrosis - RDW-Platelet Ratio (RPR), Neutrophil to Lymphocyte ratio, Platelet to Lymphocyte ratio, GGT to Platelet ratio, AST-Platelet Ratio index and AST-ALT Ratio were calculated. The noninvasive markers of fibrosis –GGT to Platelet ratio, AST to platelet ratio and AST to ALT ratio were significantly higher in test subjects (0.06±0.11; 0.44±0.87; 1.49±0.86) compared with control subjects (0.02±0.01;0.11± 0.69;0.89±0.59 respectively, p<0.001). Some Liver function tests studied –gamma glutamyl transferase, alkaline phosphatase aspartate transaminase and alanine transaminase were all significantly higher in test subjects 4.60±1.66U/L, 40.30±14.50U/L, 11.61±5.13U/L and 9.10±2.94U/L) compared with the control group(9.15±1.75µmol/l, 2.33±0.78U/L,28.89±5.17U/L, 5.98±0.11U/L and 7.07±1.49U/L). This study showed that noninvasive markers of fibrosis play significant role in HBV management but should not be used as its alternative.[Full Text Article]