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COMPARATIVE ANALYSIS OF THE IMPACT OF HUMAN IMMUNE-DEFICIENCY VIRUS ON FERTILITY VARIABLES OF COMMERCIAL MOTOCYCLISTS AND NON-CYCLISTS IN NNEWI, SOUTH-EAST NIGERIA
Ochiabuto O. M. T. B.* and Chukwura. E. I.
Background: Human immunodeficiency virus infection (HIV), a global epidemic especially in high-risk occupational groups, impacts negatively on fertility parameters and male- fertility. Methodolgy: A case-control study of thecomparative analysis on the impact of Human Immune-deficiency Virus on fertility variables of commercial motorcyclists and non-cyclists in Nnewi, South-East Nigeriawas conducted. A total of 152 males consisting of 49 commercialmotorcyclists and 103 non-cyclists of age-ranges of 19-79 years old was used. Pre-tested questionnaires and tools were used for data collection for variables; hormones were assessed by immunoassay technique, HIV virus was screened immune-chromatographically using parallel testing, positive samples confirmed with Western-blot technique, semen biomarkers (FSH,LH, prolactin, progesterone, testosterone) by Enzyme Linked Imunosorbent Assay (ELISA), semen qualities with new WHO methods, modified to suit sperm; fertility index and observed fertility index was mathematically-derived. Biologically important semen quality parameters were calculatedwith standard WHO mathematical-deduction method. Results: Results revealed a total of 4(2.6%) were HIV-1 infected; 3(6.1%) from tests and 1(1.0%) from controls. Positive HIV status impacted negatively significantly on observed fertility status (U2 = 136.500; P = 0.049) in all males andsome semen quality variables; (teratozoospermia <50%) in test groups (U2 = 20.500; P = 0.039), sperm concentration in both test and control groups,(U2 = 21.000; P = 0.044); (U2 = 0.000; P = 0.020)and non-significantly though with changes in mean rank values of semen biomarkers and serum hormones in HIV -1 + categories in both groups. Conclusion: HIV- 1 status significantly reduced and affected mean rank of testosterone hormones, teratozoospermia cells and sperm concentration semen qualities and observed fertility status incommercial motorcyclists than in non-cyclists reducing their fertilitypotential. Awareness is needed on the need for early detection and care as it can reduce male fertility.[Full Text Article]