WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Ayodeji David Adeoye*, Bayo Olufunso Adeoye, Moromoke Ajisope Fadunsin,
Okikiola Olamide Olanrewaju, Lola Adeola Adelakin

ABSTRACT

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms due to the loss of dopaminergic neurons. While current treatments can help manage symptoms, they are limited in their effectiveness and have side effects. This study investigates the potential of honey as an adjuvant therapy for PD by examining its bioactive compounds and their roles in modulating molecular pathways associated with PD. The phytochemical, vitamin, amino acid, and fatty acid composition of a sweet honey sample were analyzed using standard analytical techniques. Network pharmacology-based analyses were then conducted to identify potential target genes and signaling pathways that could be influenced by the honey phytoconstituents. The results revealed that the honey sample contained a diverse array of bioactive compounds, including phenolic compounds, unsaturated fatty acids, vitamins, and amino acids. Network analysis identified 336 consensus genes that were common between the honey components and PD-associated genes. These genes were significantly enriched in pathways related to synaptic signaling, oxidative stress response, and neuronal structure and function - all of which are implicated in PD pathogenesis. The study provides evidence that the bioactive compounds in honey have the potential to exert neuroprotective and disease-modifying effects in PD by targeting key molecular pathways. These findings support the further investigation of honey as a complementary and integrative approach to PD management. However, rigorous experimental validation is needed to fully elucidate the mechanisms of action and determine the optimal dosing and formulations for clinical use.

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