WORLD JOURNAL OF ADVANCE
HEALTHCARE RESEARCH

Suleiman N.2, Bulama I., Muhammad N. I., Jimoh A. A., Buhari S. and Bilbis L. S.

ABSTRACT

Rapid increase in the production of reactive oxygen species (ROS) immediately after ischemic stroke quickly overwhelm the antioxidant defenses of the body, thereby causing neuronal dysfunction, tissue damage and cell death. This research reports the effects of Vitamins C and E on the antioxidant enzymes and electrolytes status of Wistar rats induced with ischemic stroke (IS). Twenty apparently healthy rats were divided into four groups of five rats each. IS was induced using middle cerebral artery occlusion (MCAO). Vitamins C and Vitamin E at 45mg/kg body weight were orally administered to the rats for two weeks, antioxidant enzymes (catalase (CAT) superoxide dismutase (SOD) and glutathione peroxide (GPX) activities and oxidative stress biomarkers (thiobarbituric acid reactive species (TBARS) concentration, were assessed. Blood glucose and serum electrolyte status were also assessed. IS caused significantly (p<0.05) decrease in the activities of SOD, CAT and GPx and significant increase (P<0.05) in the concentration of TBARS. IS also caused significant increase (P<0.05) in electrolytes and glucose level in the IS rats. Treatment with vitamins C and E resulted in the significant increase (P<0.05) of the activities of CAT, SOD and GPX. Also, there was significant (p<0.05) decrease in the concentration of TBARS. There was significant (P<0.05) decrease in the electrolytes and glucose level of the IS rats following the treatments. Supplementation with Vitamins C and E reduced oxidative stress and its biomarkers in induced ischemic stroke in rats and may be a good therapeutic strategies for the management of IS.